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Differences in clinical outcomes among hepatitis C genotype 1-infected patients treated with peginterferon alpha-2a or peginterferon alpha-2b plus ribavirin: a meta-analysis
Author(s) -
Edward J. Mills,
Mills
Publication year - 2012
Publication title -
clinical and experimental gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 30
ISSN - 1178-7023
DOI - 10.2147/ceg.s28253
Subject(s) - ribavirin , medicine , discontinuation , gastroenterology , alpha interferon , hepatitis c , alpha (finance) , randomized controlled trial , relative risk , meta analysis , combination therapy , clinical trial , peginterferon alfa 2a , confidence interval , chronic hepatitis , surgery , virology , interferon , virus , construct validity , patient satisfaction
With the development of new direct acting antiviral (DAA) therapy for hepatitis C, the backbone peginterferon alpha used may be of importance in maximizing treatment outcomes. To this end, the rates of sustained virologic response (SVR), relapse, and treatment discontinuation among hepatitis C genotype 1-infected patients given peginterferon alpha-2a plus ribavirin or peginterferon alpha-2b plus ribavirin were determined using a meta-analysis.

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