Oral metronidazole as antibiotic prophylaxis for patients with nonperforated appendicitis | Zendy

Hassan Ravari | Zendy; Jangjoo | Zendy; Motamedifar | Zendy; Moazzami | Zendy

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Oral metronidazole as antibiotic prophylaxis for patients with nonperforated appendicitis

Author(s) -

Hassan Ravari,

Jangjoo,

Motamedifar,

Moazzami

Publication year - 2011

Publication title -

clinical and experimental gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.113

H-Index - 30

ISSN - 1178-7023

DOI - 10.2147/ceg.s18153

Subject(s) - medicine , metronidazole , antibiotics , appendicitis , antibiotic prophylaxis , surgery , randomized controlled trial , anesthesia , microbiology and biotechnology , biology

The rate of wound infection after appendectomy without antibiotic prophylaxis is 10%-30%. The role of prophylactic antibiotic therapy in nonperforated appendicitis is still controversial. Metronidazole is against anaerobic organisms and its bioavailability after oral and parenteral administration has been shown to be similar. The objective of the present study is to compare the infective complications rate after open appendectomy for nonperforated appendicitis receiving either oral or intravenous metronidazole as prophylaxis.

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