OnabotulinumtoxinA in the treatment of neurogenic bladder | Zendy

Altaf Mangera | Zendy; Gulamhusein | Zendy

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OnabotulinumtoxinA in the treatment of neurogenic bladder

Author(s) -

Altaf Mangera,

Gulamhusein

Publication year - 2012

Publication title -

biologics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.948

H-Index - 38

eISSN - 1177-5491

pISSN - 1177-5475

DOI - 10.2147/btt.s30180

Subject(s) - dyssynergia , medicine , botulinum toxin , detrusor sphincter dyssynergia , dosing , urinary system , overactive bladder , urology , anesthesia , surgery , neurological disorder , central nervous system disease , alternative medicine , pathology

This review examines the evidence for use of onabotulinumtoxinA in the treatment of neurogenic lower urinary tract dysfunction. Since its first use in 1988 to treat detrusor sphincter dyssynergia, use of botulinum toxin has increased in this group of patients. We discuss the mechanism of action, patient selection, dosing, efficacy, and side effect profile of this now licensed treatment option.

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