Affinity of estrogens for human progesterone receptor A and B monomers and risk of breast cancer: a comparative molecular modeling study | Zendy

Tarique N. Hasan | Zendy; Masoodi | Zendy; Grace | Zendy; Shafi | Zendy; Ali A. Alshatwi | Zendy

Open Access

Affinity of estrogens for human progesterone receptor A and B monomers and risk of breast cancer: a comparative molecular modeling study

Author(s) -

Tarique N. Hasan,

Masoodi,

Grace,

Shafi,

Ali A. Alshatwi

Publication year - 2011

Publication title -

advances and applications in bioinformatics and chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.223

H-Index - 15

ISSN - 1178-6949

DOI - 10.2147/aabc.s17371

Subject(s) - breast cancer , progesterone receptor , human breast , cancer , receptor , monomer , chemistry , estrogen receptor , endocrinology , medicine , organic chemistry , polymer

The human progesterone receptor (hPR) belongs to the steroid receptor family. It may be found as monomers (A and B) and or as a dimer (AB). hPR is regarded as the prognostic biomarker for breast cancer. In a cellular dimer system, AB is the dominant species in most cases. However, when a cell coexpresses all three isoforms of hPR, the complexity of the action of this receptor increases. For example, hPR A suppresses the activity of hPR B, and the ratio of hPR A to hPR B may determine the physiology of a breast tumor. Also, persistent exposure of hPRs to nonendogenous ligands is a common risk factor for breast cancer. Hence we aimed to study progesterone and some nonendogenous ligand interactions with hPRs and their molecular docking.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research