Open AccessSignal Transduction by Type I Interferons
Author(s) -
Michael David
Publication year - 2002
Publication title -
biotechniques
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.617
H-Index - 131
eISSN - 1940-9818
pISSN - 0736-6205
DOI - 10.2144/oct0207
Subject(s) - signal transduction , interferon , biology , transduction (biophysics) , interferon type i , cytokine , immunology , cell type , microbiology and biotechnology , genetics , cell , biochemistry
The two classes of interferons, type I (IFNalpha, IFNbeta, IFNomega, and IFNtau) and type II (IFNgamma) are pleiotropic cytokines that exhibit antiviral, antiproliferative, and immunomodulatory effects on their target cells. This article summarizes the advances made in elucidating the molecular events that mediate the biological responses to type I interferons.
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