Overcoming Negative Predictions of microRNA Expressions to Gemcitabine Response With FOLFIRINOX in Advanced Pancreatic Cancer Patients | Zendy

Konstantin Schlick | Zendy; Florian Hohla | Zendy; Frank Hamacher | Zendy; Hubert Hackl | Zendy; Clemens Hufnagl | Zendy; Steiner Markus | Zendy; Teresa Magnes | Zendy; Simon Peter Gampenrieder | Zendy; Thomas Melchardt | Zendy; Stefan Stättner | Zendy; Cornelia HauserKronberger | Zendy; Richard Greil | Zendy; Gabriel Rinnerthaler | Zendy

Open Access

Overcoming Negative Predictions of microRNA Expressions to Gemcitabine Response With FOLFIRINOX in Advanced Pancreatic Cancer Patients

Author(s) -

Konstantin Schlick,

Florian Hohla,

Frank Hamacher,

Hubert Hackl,

Clemens Hufnagl,

Steiner Markus,

Teresa Magnes,

Simon Peter Gampenrieder,

Thomas Melchardt,

Stefan Stättner,

Cornelia HauserKronberger,

Richard Greil,

Gabriel Rinnerthaler

Publication year - 2020

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.2144/fsoa-2020-0128

Subject(s) - folfirinox , gemcitabine , microrna , pancreatic cancer , oncology , medicine , drug resistance , regimen , cancer research , cancer , irinotecan , biology , gene , biochemistry , colorectal cancer , microbiology and biotechnology

FOLFIRINOX is superior to gemcitabine in patients with pancreatic cancer, but this regimen is associated with toxicity and biomarkers for response are warranted. MicroRNAs can mediate drug resistance and could provide predictive information. Altered expressions of several microRNAs including miR-21-5p, miR-10b-5p and miR-34a-5p have been previously linked to a worse response to gemcitabine. We investigated the influence of expression levels in tumor tissue of those three microRNAs on outcome to FOLFIRINOX. Twenty-nine patients with sufficient formalin-fixed paraffin-embedded tumor tissue were identified. There was no significant association between high and low expression groups for these three microRNA. We conclude that polychemotherapy combination can overcome intrinsic negative prognostic factors.

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