Assessment of Noninvasive Positive Pressure Ventilation in Healthy Young Volunteers Using Salivary Stress Biomarkers | Zendy

Yuri Fueda | Zendy; Fuka Matsuda | Zendy; Takuya Kataoka | Zendy

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Assessment of Noninvasive Positive Pressure Ventilation in Healthy Young Volunteers Using Salivary Stress Biomarkers

Author(s) -

Yuri Fueda,

Fuka Matsuda,

Takuya Kataoka

Publication year - 2020

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.2144/fsoa-2019-0150

Subject(s) - chromogranin a , saliva , medicine , ventilation (architecture) , positive pressure ventilation , respiratory system , immunohistochemistry , mechanical engineering , engineering

Aim: We performed a stress assessment of noninvasive positive pressure ventilation (NPPV) using the salivary biomarkers chromogranin A. Materials & methods: Twenty healthy volunteers were subjected to NPPV for 30 min. We collected saliva samples before and after NPPV and evaluated chromogranin A. Results: We collected saliva samples from 13 volunteers for enzyme measurement. Of the 13 volunteers, 11 showed elevated chromogranin A levels, which were significantly higher after NPPV than before NPPV (p < 0.01). The chromogranin A increase group displayed significantly increased leak flow and reduced respiratory rate and absolute humidity compared with the chromogranin A reduction group. Conclusion: The increase of leak volume might be a stress factor in patients receiving NPPV.

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