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Aim:  To determine the expression patterns of the  RBBP6  spliced variants during arsenic trioxide-mediated cell cycle arrest and curcumin-induced apoptosis in MCF-7 cells.    Materials & methods:  As 2 O 3  and curcumin were used to study cytotoxicity, cell cycle arrest, apoptosis and the expression of  RBBP6  variants. The MUSE Cell Analyser was used to analyze cell cycle arrest, apoptosis and multicaspase activity while apoptosis was further confirmed using microscopy. Semi-quantitative RT-PCR was employed to quantitate the expression of the  RBBP6  variants.    Results:  This study showed that the MCF-7 cells expressed  RBBP6  variant 1 but lacked both variant 2 and variant 3. Both As 2 O 3  and curcumin significantly downregulated  RBBP6  variant 1 (p < 0.001).    Conclusion:   RBBP6  variants are promising therapeutic targets.

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Downregulation of <i>RBBP6</i> variant 1 during arsenic trioxide-mediated cell cycle arrest and curcumin-induced apoptosis in MCF-7 breast cancer cells

Downregulation of RBBP6 variant 1 during arsenic trioxide-mediated cell cycle arrest and curcumin-induced apoptosis in MCF-7 breast cancer cells