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Aim:  A rapid UPLC–MS/MS method for the determination of tamoxifen (TAM),  N -desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in human plasma was validated, after a simple protein precipitation.    Materials and methods:  The analysis was achieved on a C 18  analytical column, using a gradient elution with a mobile phase of water and acetonitrile for 4.5 min.    Results:  The validated method demonstrated good linearity between 1 and 500 ng/ml for TAM and  N -desmethyltamoxifen; between 0.2 and 100 ng/ml for endoxifen and between 0.1 and 50 ng/ml for 4-hydroxytamoxifen. The method also provided satisfactory results in terms of within day and between day imprecisions and accuracy, and also in terms of time stability and specificity.    Conclusion:  The method is applied routinely for TAM monitoring from patients undergoing therapy.

New UPLC–MS/MS assay for the determination of tamoxifen and its metabolites in human plasma, application to patients