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Aim:  Endothelial cells (ECs), isolated from peripheral blood (PB), bone marrow (BM) and cord blood (CB), are limited in numbers and expansion has had limited success. We used a novel serum-free medium (EndoGo) to evaluate effects on  ex vivo  expansion of CB-derived ECs.    Materials & methods:  Flow cytometry and matrigel were used to determine expansion of ECs and for determination of the EC progenitor cell.    Results:  EndoGo™-containing cultures demonstrated superior expansion and stimulated proliferation of two distinct subpopulations, CD34 + CD31 +  and CD34 - CD31 + , which exhibited different morphology, phenotype and function. EndoGo also expanded the CB endothelial progenitor cells from freshly isolated CB.    Conclusion:  These findings demonstrate the potential of EndoGo to expand CB ECs, which could generate increased numbers of ECs for therapeutic applications.

Ex vivo expansion of cord blood-derived endothelial cells using a novel xeno-free culture media