Open AccessMembrane Biochips
Author(s) -
Fang Ye,
Anthony G. Frutos,
Brian Webb,
Yulong Hong,
Ann M. Ferrie,
Fang Lai,
Joydeep Lahiri
Publication year - 2002
Publication title -
biotechniques
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.617
H-Index - 131
eISSN - 1940-9818
pISSN - 0736-6205
DOI - 10.2144/dec02fang
Subject(s) - biochip , dna microarray , g protein coupled receptor , computational biology , protein microarray , membrane protein , membrane , microarray , ligand (biochemistry) , biology , nanotechnology , receptor , chemistry , bioinformatics , gene , biochemistry , materials science , gene expression
Membrane-bound proteins represent the single most important class of drug targets. This article discusses the issues surrounding fabrication of membrane-protein microarrays by conventional robotic pin printing techniques. Ligand binding selectivity and specificity to G protein-coupled receptor (GPCR) microarrays are presented. The potential applications of these arrays for drug screening are discussed.
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