Cost-effective storage solution for delivering umbilical cord with efficient isolation of mesenchymal stem cells | Zendy

Baoyu Lai | Zendy; Jieyong Huang | Zendy; Jieting Chen | Zendy; Wenlei Li | Zendy; Huimei Wu | Zendy; Jianyong Xu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cost-effective storage solution for delivering umbilical cord with efficient isolation of mesenchymal stem cells

Author(s) -

Baoyu Lai,

Jieyong Huang,

Jieting Chen,

Wenlei Li,

Huimei Wu,

Jianyong Xu

Publication year - 2020

Publication title -

biotechniques

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.617

H-Index - 131

eISSN - 1940-9818

pISSN - 0736-6205

DOI - 10.2144/btn-2019-0146

Subject(s) - mesenchymal stem cell , umbilical cord , isolation (microbiology) , fetal bovine serum , regenerative medicine , stem cell , chemistry , immunology , medicine , bioinformatics , biology , microbiology and biotechnology , biochemistry , pathology , in vitro

Mesenchymal stem cells (MSCs) represent a promising therapeutic candidate for treating many diseases. However, their proliferation and therapeutic abilities decline during the aging process and disease development. Therefore, fetal MSCs derived from the umbilical cord (UC) attract more attention. Storing and delivering the UC is one critical step for efficient MSC isolation. Although the culture medium-based solution is suitable for UC storage, it is not feasible for large-scale preparation because of its high price. Thus, we demonstrate here that a simple solution containing a pH buffering reagent, calcium, magnesium and glucose could be used as a cost-effective storage solution for UC delivery and efficient MSC isolation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research