GELSTATS: A Computer Program for Population Genetics Analyses Using VNTR Multilocus Probe Data
Author(s) -
Steven H. Rogstad,
Stephan Pelikan
Publication year - 1996
Publication title -
biotechniques
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.617
H-Index - 131
eISSN - 1940-9818
pISSN - 0736-6205
DOI - 10.2144/96216bc05
Subject(s) - genetics , biology , population , loss of heterozygosity , jackknife resampling , population genetics , similarity (geometry) , nonparametric statistics , linkage (software) , minisatellite , microsatellite , statistics , mathematics , computer science , artificial intelligence , allele , gene , demography , estimator , sociology , image (mathematics)
GELSTATS, a computer program for population genetics analyses utilizing genetic markers revealed with variable number tandem repeat (VNTR) multilocus probes, is described and made available (both as C++ source code and as an executable DOS program). The program calculates several population genetics parameters, including: (i) individual and population band numbers; (ii) population bands exhibiting complete linkage (redundant examples of such bands can be removed in subsequent analyses); (iii) similarity (fraction of bands shared) between individuals and average similarity within and between designated groups; (iv) estimated probability that two individuals chosen at random will have identical band profiles; (v) heterozygosity estimates for designated groups; and (vi) Fst estimates. Nonparametric permutation methods are used to assess the significance of differences in both within- and between-group similarity. A jackknife test for heterozygosity differences between groups is also computed. Examples of GELSTATS analyses illustrate some features of the program.
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