Accelerator Mass Spectrometry for Quantitative in Vivo Tracing | Zendy

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Accelerator Mass Spectrometry for Quantitative in Vivo Tracing

Author(s) -

John S. Vogel

Publication year - 2005

Publication title -

biotechniques

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.617

H-Index - 131

eISSN - 1940-9818

pISSN - 0736-6205

DOI - 10.2144/05386su04

Subject(s) - accelerator mass spectrometry , isotope , mass spectrometry , in vivo , chemistry , radiochemistry , tracing , stable isotope ratio , isotopes of carbon , chromatography , biology , nuclear physics , computer science , operating system , physics , microbiology and biotechnology

Accelerator mass spectrometry (AMS) counts individual rare, usually radio-, isotopes such as radiocarbon at high efficiency and specificity in milligram-sized samples. AMS traces very low chemical doses (micrograms) and radiative doses (100 Bq) of isotope-labeled compounds in animal models and directly in humans for pharmaceutical, nutritional, or toxicological research. Absorption, metabolism, distribution, binding, and elimination are all quantifiable with high precision after appropriate sample definition.

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