Identification of Differentially Expressed Genes from Ovarian Cancer Cells by MICROMAX™ cDNA Microarray System | Zendy

KwongKwok Wong | Zendy; Rita Cheng | Zendy; Samuel C. Mok | Zendy

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Identification of Differentially Expressed Genes from Ovarian Cancer Cells by MICROMAX™ cDNA Microarray System

Author(s) -

KwongKwok Wong,

Rita Cheng,

Samuel C. Mok

Publication year - 2001

Publication title -

biotechniques

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.617

H-Index - 131

eISSN - 1940-9818

pISSN - 0736-6205

DOI - 10.2144/01303dd05

Subject(s) - complementary dna , biology , gene , microarray , identification (biology) , ovarian cancer , genetics , microarray analysis techniques , gene expression , microbiology and biotechnology , cancer , gene expression profiling , computational biology , botany

Using the MICROMAX cDNA microarray system, we were able to identify genes that are differentially overexpressed in ovarian cancer. A total of 30 putative genes, which are differentially overexpressed in ovarian cancer cell lines, were identified. The differential expression of some of these genes was further confirmed by real-time RT-PCR. Using this strategy, we have identified genes that either overexpress in all cancer cell lines or in only some cancer cell lines. Further characterization of these genes will allow them to be exploited in diagnosis, prognosis, anticancer therapy, and molecular classification of ovarian cancer.

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