Low Titer Lentiviral Transgenesis in Rodents with Simian Immundeficiency Virus Vector | Zendy

Balázs Bender | Zendy; Orsolya Ivett Hoffmann | Zendy; Didier Négre | Zendy; Krisztián Kvell | Zendy; Zsuzsanna Bösze | Zendy; László Hiripi | Zendy

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Low Titer Lentiviral Transgenesis in Rodents with Simian Immundeficiency Virus Vector

Author(s) -

Balázs Bender,

Orsolya Ivett Hoffmann,

Didier Négre,

Krisztián Kvell,

Zsuzsanna Bösze,

László Hiripi

Publication year - 2013

Publication title -

biotechniques

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.617

H-Index - 131

eISSN - 1940-9818

pISSN - 0736-6205

DOI - 10.2144/000114078

Subject(s) - titer , virology , microinjection , transgenesis , transgene , biology , simian , virus , viral vector , vector (molecular biology) , recombinant dna , embryo , genetics , microbiology and biotechnology , gene , embryogenesis , reproductive biology

Efficient production of transgenic animals using low-titer lentiviral constructs remains challenging. Here we demonstrate that microinjection of simian immundeficiency virus-derived lentiviral constructs can produce transgenic mice and rats with high efficiency even when using low-titer virus preparations.

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