Interferon Gamma: Activity and ELISA Detection Comparisons | Zendy

Sara Crisafulli | Zendy; Yognandan Pandya | Zendy; Karlene Moolchan | Zendy; Thomas Lavoie | Zendy

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Interferon Gamma: Activity and ELISA Detection Comparisons

Author(s) -

Sara Crisafulli,

Yognandan Pandya,

Karlene Moolchan,

Thomas Lavoie

Publication year - 2008

Publication title -

biotechniques

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.617

H-Index - 131

eISSN - 1940-9818

pISSN - 0736-6205

DOI - 10.2144/000112943

Subject(s) - interferon gamma , virology , biology , immunology , cytokine

Interferon-gamma (IFN-γ) is a pleiotropic cytokine secreted by Natural Killer (NK) cells and many T cells. It is the sole representative of Type II IFN. IFN-γ has pleiotropic activities including: inducing an antiviral state in cells, upregulating cell surface markers such as Class I and II MHC, and regulating the activity of macrophages, NK cells, neutrophils, B-cells, and T-cells. As such, IFN-γ is one of the most widely studied proteins [Scroder et al (2004) J. Leuk. Biol. 75:163; Young and Bream (2007) Curr. Top. Microbiol. Immunol. 316:97].

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