High-throughput profiling of posttranslational modification enzymes by phage display | Zendy

Michelle Yen | Zendy; Jun Yin | Zendy

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High-throughput profiling of posttranslational modification enzymes by phage display

Author(s) -

Michelle Yen,

Jun Yin

Publication year - 2007

Publication title -

biotechniques

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.617

H-Index - 131

eISSN - 1940-9818

pISSN - 0736-6205

DOI - 10.2144/000112502

Subject(s) - phage display , proteome , enzyme , biology , genome , computational biology , biochemistry , high throughput screening , chemistry , gene , peptide

Phage display has been used as a high-throughput platform for identifying proteins or peptides with desired binding or catalytic activities from a complex proteome. Recently, phage display has been applied to profile the catalytic activities of posttranslational modification (PTM) enzymes. Here, we highlight recent work elucidating the downstream targets of PTM enzymes by phage display, including the genome-wide profiling of biosynthetic enzymes subject to phosphopantetheinyl transferase (PPTase) modification.

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