Open AccessEffects of vitamin E on neurodegenerative diseases: an update
Author(s) -
Mehmet Arif İçer,
Neslihan Arslan,
Makbule Gezmen Karadağ
Publication year - 2021
Publication title -
acta neurobiologiae experimentalis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 55
eISSN - 1689-0035
pISSN - 0065-1400
DOI - 10.21307/ane-2021-003
Subject(s) - neurodegeneration , amyotrophic lateral sclerosis , disease , medicine , oxidative stress , vitamin d and neurology , multiple sclerosis , stroke (engine) , neuroscience , vitamin e , neuroprotection , vitamin , bioinformatics , immunology , biology , antioxidant , mechanical engineering , biochemistry , engineering
Vitamin E deficiency is associated with many neurological problems. Although the mechanisms of vitamin E action in neurodegenerative diseases are not clear, there are many possible mechanisms. Examples of such mechanisms are the protective effects of vitamin E against oxidative stress damage and its suppressive role in the expression of many genes involved in the development of neurodegeneration. Many studies have evaluated the relationship between vitamin E intake or vitamin E levels in body fluids and neurodegenerative diseases. Some studies concluded that vitamin E can play a protective role in neurodegeneration with respect to diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), stroke and amyotrophic lateral sclerosis (ALS). Vitamin E supplementation was also associated with risk factors for some neurodegenerative diseases. In this review, we discuss the possible effects of vitamin E on the development and course of AD, PD, stroke and ALS, and the potential mechanisms involved.
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