Formulation Development and Evaluation of In-Situ Nasal Gel of Lisinopril Dihydrate

The present study was aimed to develop a mucoadhesive In-situgel of Lisinopril Dihydrate for improved bioavailability by circumventing the hepatic first pass metabolism and patient compliance. Lisinopril dihydrate was incorporated into the blends of thermo reversible polymer pluronic F 188(PF 188) and bio adhesive polymer Carbopol 934 in the form of In-situgel by cold technique to reduce the mucociliary clearance, and thereby it will increase the contact of formulation with nasal mucosa and hence improving drug absorption. The prepared gels were characterized by pH, Drug content, Gel strength, in -vitro drug release studies, stability study etc. The pH of all the formulations were found to be within the range between 4.5-6.5 and the nasal mucosa can tolerate the above mentioned pH of the formulations. The drug content of all formulations was found to be 91.09 to 99.98%. Viscosity measurement of the formulations at temperatures 25°C & 37°C shows that there was increase in viscosity with increase in the temperature and it was found that all formulations were in liquid state at room temperature and were converted into gel at nasal physiological temperature. The optimized formulation showed a drug release of 98.83% in 8 hrs.