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The objective of present study was to prepare a novel stable Fluorometholone ophthalmic Nanosuspension which has advantage over conventional ophthalmic suspension such as blurred vision, burning, stinging and irritation upon instillation. The viscosity was increased to provide additional advantage of long duration of action. Precipitation method was used to prepare Fluorometholone ophthalmic Nanosuspension. The type of polymer and stabilizer used showed effect on the particle size and zeta potential of Fluorometholone. Viscosity of prepared Nanosuspension was carried out which is sufficient to give better retention with cornea. The in-vitro drug release study showed that the optimized Nanosuspension released 98.87% of the drug within 8 hours. Stability study was carried out as per ICH guidelines.

Formulation and Characterization of Fluorometholone Nanosuspension for Ophthalmic Drug Delivery by Precipitation Method