Design, Synthesis and Antibacterial Evaluation of Some New Pyrazolinyl Bromophenylthiazoles

In this study a stepwise reaction has been designed for the synthesis of some new    derivatives of Pyrazolinyl bromophenylthiazoles. The progress started by the benzylation of  2,4-dihydroxyacetophenone to give   1-[2,4-bis(4-chlorobenzyloxy)phenyl]ethanone  (1) which was reacted with a number of  benzaldehydes to produce a series of new α,β-unsaturated carbonyl compounds (2a-j). Followed by Michael addition with thiosemicarbazide affording new pyrazolines bearing thiocarbamoyl group(3a-j). A later derivatives were treated with 4-bromophenacyl-bromide  yielding  a series of a target pyrazolines having a thiazole linkages(4a-j).The final products were screened for their antimicrobial evaluations using micro broth  dilution method  against S.aureus as gram positive and  E.Coli as gram negative.Spectroscopic techniques were utilized to elucidate  the structures of the prepared compounds.