MRI-Derived Cellularity Index as a Potential Noninvasive Imaging Biomarker of Prostate Cancer

: Standard magnetic resonance imaging (MRI) of the prostate lacks sensitivity in the diagnosis and staging of prostate cancer (PCa). To improve the operating characteristics of prostate MRI in the detection and characterization of PCa, we developed a novel, enhanced MRI diffusion technique using restriction spectrum imaging (RSI-MRI). This technique leads to greater tumor conspicuity and also more accurate localization due to spatial distortion correction techniques. As of this annual report, we show that these techniques increase our ability to detect extraprostatic extension, improve accuracy of targeted biopsies and we show that our quantitative imaging signal (RSI z-score) correlates with Gleason grade on final histopathology.