Biological and Genomic Differences of ERG Oncoprotein-Stratified Prostate Cancers from African and Caucasian Americans

: There is striking disparity in prostate cancer (CaP) incidence and mortality for African-American (AA) men as compared to Caucasian Americans (CA). Biological basis for this disparity has not been established. Oncogenic activation of ERG resulting from prevalent gene fusions is present in two thirds of CaP patients in Western countries.