Effect of a HIF-1 Alpha Polymorphism on the Incidence and Prostate Cancer | Zendy

Glenn J. Bubley | Zendy

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Effect of a HIF-1 Alpha Polymorphism on the Incidence and Prostate Cancer

Author(s) -

Glenn J. Bubley

Publication year - 2007

Language(s) - English

Resource type - Reports

DOI - 10.21236/ada470130

Subject(s) - prostate cancer , alpha (finance) , biology , incidence (geometry) , polymorphism (computer science) , oncology , prostate , genetics , medicine , cancer , gene , allele , physics , surgery , construct validity , optics , patient satisfaction

: The P582S C->T and A588T G->A polymorphisms in the Hypoxia-inducible factor-1alpha (HIF-1alpha ) gene have been associated with enhanced stability of the protein and androgen-independent prostate cancer (CaP) During the course of our research we published that P582S polymorphism was not associated with CaP (see appendix). However we observed a significant interaction of the P582S genotype with insulin-like growth factor binding protein (IGFBP)-3 in modifying CaP risk such that higher IGFBP-3 levels (>= versus

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