Open AccessPhenylboronic Acid-based 19F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change
Author(s) -
Hiroshi aka,
Qi An,
Fuminori Sugihara,
Tomohiro Doura,
Akira Tsuchiya,
Yoshichika Yoshioka,
Shinsuke Sando
Publication year - 2015
Publication title -
analytical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.392
H-Index - 73
eISSN - 1348-2246
pISSN - 0910-6340
DOI - 10.2116/analsci.31.331
Subject(s) - chemistry , hydrogen peroxide , phenylboronic acid , boronic acid , fluorine 19 nmr , organic chemistry , nuclear magnetic resonance spectroscopy , catalysis
Herein, we report on a new (19)F MRI probe for the detection and imaging of H2O2. Our designed 2-fluorophenylboronic acid-based (19)F probe promptly reacted with H2O2 to produce 2-fluorophenol via boronic acid oxidation. The accompanying (19)F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H2O2 by (19)F chemical-shift-selective MRI.