Phenylboronic Acid-based 19F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change | Zendy

Hiroshi aka | Zendy; Qi An | Zendy; Fuminori Sugihara | Zendy; Tomohiro Doura | Zendy; Akira Tsuchiya | Zendy; Yoshichika Yoshioka | Zendy; Shinsuke Sando | Zendy

Open Access

Phenylboronic Acid-based 19F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

Author(s) -

Hiroshi aka,

Qi An,

Fuminori Sugihara,

Tomohiro Doura,

Akira Tsuchiya,

Yoshichika Yoshioka,

Shinsuke Sando

Publication year - 2015

Publication title -

analytical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.392

H-Index - 73

eISSN - 1348-2246

pISSN - 0910-6340

DOI - 10.2116/analsci.31.331

Subject(s) - chemistry , hydrogen peroxide , phenylboronic acid , boronic acid , fluorine 19 nmr , organic chemistry , nuclear magnetic resonance spectroscopy , catalysis

Herein, we report on a new (19)F MRI probe for the detection and imaging of H2O2. Our designed 2-fluorophenylboronic acid-based (19)F probe promptly reacted with H2O2 to produce 2-fluorophenol via boronic acid oxidation. The accompanying (19)F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H2O2 by (19)F chemical-shift-selective MRI.

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