Acetone Concentration in Gas Emanating from Tails of Diabetic Rats | Zendy

Kazuaki Yamai | Zendy; Toshiaki Funada | Zendy; Tetsuo Ohkuwa | Zendy; Hiroshi Itoh | Zendy; Takao Tsuda | Zendy

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Acetone Concentration in Gas Emanating from Tails of Diabetic Rats

Author(s) -

Kazuaki Yamai,

Toshiaki Funada,

Tetsuo Ohkuwa,

Hiroshi Itoh,

Takao Tsuda

Publication year - 2012

Publication title -

analytical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.392

H-Index - 73

eISSN - 1348-2246

pISSN - 0910-6340

DOI - 10.2116/analsci.28.511

Subject(s) - chemistry , acetone , chromatography , environmental chemistry , organic chemistry

This study investigated the effects of diabetic rats induced by streptozotocin (STZ) on acetone concentration emanating from the tail of a rat. Experiments were carried out with male Wistar rats (9 weeks of age, 220 - 250 g body weight). Glucose concentration in the blood was 10.8 ± 0.7 mmol/l for the control group and 39.6 ± 2.4 mmol/l for the diabetic group. β-Hydroxybutyrate concentration in blood was 218 ± 52 µmol/l for the control group and 1439 ± 101 µmol/l for the diabetic group. Both glucose and β-hydroxybutyrate concentrations in the blood of the diabetic group were significantly higher than those of the control group (p < 0.001). Skin gas acetone concentration emanated from rat tail was 124 ± 46 ppb for control and 1134 ± 417 ppb for diabetic. Skin gas acetone concentration emitted from the tail of a rat with diabetes was significantly higher than that from a rat in the control group (p < 0.001). The result indicates that skin acetone emanating from a rat tail is a useful parameter to use for insulin-dependent diabetes (type I).

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