Elimination Technique for Alkali Metal Ion Adducts from an Electrospray Ionization Process Using an On-line Ion Suppressor | Zendy

Kazuyoshi Nozaki | Zendy; Akira Tarui | Zendy; Issey Osaka | Zendy; Hideya Kawasaki | Zendy; Ryuichi Arakawa | Zendy

Open Access

Elimination Technique for Alkali Metal Ion Adducts from an Electrospray Ionization Process Using an On-line Ion Suppressor

Author(s) -

Kazuyoshi Nozaki,

Akira Tarui,

Issey Osaka,

Hideya Kawasaki,

Ryuichi Arakawa

Publication year - 2010

Publication title -

analytical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.392

H-Index - 73

eISSN - 1348-2246

pISSN - 0910-6340

DOI - 10.2116/analsci.26.715

Subject(s) - chemistry , adduct , ion , alkali metal , electrospray ionization , ionization , mass spectrometry , mass spectrum , ammonium , inorganic chemistry , analytical chemistry (journal) , base (topology) , chromatography , organic chemistry , mathematical analysis , mathematics

The effects of an on-line ion suppressor device on alkali metal ion adduct formations of the model compound tacrolimus were investigated. The base peak ion in the positive ion ESI-MS spectrum of tacrolimus was a sodium ion adduct, [M+Na](+). On the other hand, an ammonium ion adduct, [M+NH(4)](+), was the base peak ion in the full-scan mass spectrum of tacrolimus with a cation-exchange suppressor resin, and both [M+Na](+) and [M+K](+) were eliminated. These results indicate that the combination of an on-line ion suppressor with ESI-MS is a simple and effective technique that eliminates undesirable alkali metal ion adduct formations in the positive-ion mode.

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