An Attempt Directed toward Enhanced Shape Selectivity in Reversed-Phase Liquid Chromatography: Preparation of the Dodecylaminated β-Cyclodextrin-Bonded Phase | Zendy

Chuzo Fujimoto | Zendy; Akira Maekawa | Zendy; Yumiko Murao | Zendy; Kiyokatsu Jinno | Zendy; Tsutomu Takeichi | Zendy

Open Access

An Attempt Directed toward Enhanced Shape Selectivity in Reversed-Phase Liquid Chromatography: Preparation of the Dodecylaminated β-Cyclodextrin-Bonded Phase

Author(s) -

Chuzo Fujimoto,

Akira Maekawa,

Yumiko Murao,

Kiyokatsu Jinno,

Tsutomu Takeichi

Publication year - 2002

Publication title -

analytical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.392

H-Index - 73

eISSN - 1348-2246

pISSN - 0910-6340

DOI - 10.2116/analsci.18.65

Subject(s) - chemistry , cyclodextrin , selectivity , alkyl , phase (matter) , chromatography , reversed phase chromatography , monomer , high performance liquid chromatography , molecular recognition , stationary phase , silica gel , organic chemistry , molecule , polymer , catalysis

With the aim of preparing a stationary phase with a high shape-recognition ability for liquid chromatography, a new bonded phase was synthesized by coupling multiply dodecylamino-substituted beta-cyclodextrin (beta-CD) to 3-glycidoxypropyl-derivatized silica gel. The stationary phase prepared in this way was expected to have increased shape selectivity compared with that of conventional reversed-phase materials, due to solute interactions with the alkyl chain piles built up on the beta-CDs bonded to silica. The separation characteristics of the bonded phase were investigated using polycyclic aromatic hydrocarbons (PAHs) with different molecular shapes and compared with those of monomeric ODS and native beta-cyclodextrin-bonded phases. The newly developed stationary phase was found to be highly selective for PAHs.

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