PENAMBATAN MOLEKULER KURKUMIN DAN ANALOGNYA PADA ENZIM SIKLOOKSIGENASE-2

The objective of this study was to observe molecular interactions between cyclooxygenase-2 inhibition with curcumin and several analogues compounds In silico. This study used 7 drug compounds that curcumin, analogue 1, 2, 3, 4, etodolac, and arachidonic acid. The compound docking used was 1PXX obtained from the website of protein data bank (PDB). Agonist compounds used were arachidonic acid, etodolac antagonist compounds, whereas test compound curcumin, analogue 1, 2, 3, and 4. All compounds were docked using ArgusLab 4.0.1 applications docking process performed by the method of ArgusDock. The analysis showed that Gibs free energy (ΔG) of curcumin, analogue 2 and 3 smaller than arachidonic acid. In conclution, curcumin, analogue 2, and 3 is able to inhibit the binding of arachidonic acid.