Synthesis and Characterization of New 2-Quinolone Sulfonamide Derivatives | Zendy

Mohammed R. Ahamad | Zendy; Redha I. Al-Bayati | Zendy; Luma S. Ahamed | Zendy

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Synthesis and Characterization of New 2-Quinolone Sulfonamide Derivatives

Author(s) -

Mohammed R. Ahamad,

Redha I. Al-Bayati,

Luma S. Ahamed

Publication year - 2016

Publication title -

baghdad science journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.167

H-Index - 6

eISSN - 2411-7986

pISSN - 2078-8665

DOI - 10.21123/bsj.2016.13.4.0806

Subject(s) - sulfonamide , chemistry , ethyl acetoacetate , quinolone , benzene , hydrate , hydrazine (antidepressant) , proton nmr , coumarin , carbon 13 nmr , organic chemistry , chloride , medicinal chemistry , combinatorial chemistry , catalysis , antibiotics , chromatography , biochemistry

A series of new 2-quinolone derivatives linked to benzene sulphonyl moieties were performed by many steps: the first step involved preparation of different coumarins (A1,A2) by condensation of different substituted phenols with ethyl acetoacetate. The compound A1 was treated with nitric acid to afford two isomers of nitrocoumarin derivatives (A3) and (A4). The prepared compounds (A2, A3) were treated with hydrazine hydrate to synthesize different 2-quinolone compounds (A5,A6) while the coumarin treated with different amines gave compounds (A7,A8). Then the synthesized 2-quinolone compounds (A5-A8) treated with benzene sulphonyl chloride to afford new sulfonamide derivatives (A9-A12). The synthesized compounds were characterized by FT-IR, 1 H-NMR, 13 C-NMR spectra and by measurement some of their physical properties.

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