Interferon-α/β Receptor as a Prognostic Marker in Osteosarcoma | Zendy

Tadahiko Kubo | Zendy; Shoji Shimose | Zendy; Toshihiro Matsuo | Zendy; Jun Fujimori | Zendy; Koji Arihiro | Zendy; Mitsuo Ochi | Zendy

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Interferon-α/β Receptor as a Prognostic Marker in Osteosarcoma

Author(s) -

Tadahiko Kubo,

Shoji Shimose,

Toshihiro Matsuo,

Jun Fujimori,

Koji Arihiro,

Mitsuo Ochi

Publication year - 2011

Publication title -

journal of bone and joint surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.634

H-Index - 260

eISSN - 1058-2436

pISSN - 0021-9355

DOI - 10.2106/jbjs.j.00198

Subject(s) - osteosarcoma , medicine , interferon , biopsy , oncology , multivariate analysis , pathology , immunology

A large-scale randomized trial of adjuvant interferon-α therapy for patients with osteosarcoma has been initiated as a joint protocol by the European and American Osteosarcoma Study Group. Because the expression of functional interferon-α/β receptor is necessary for interferon-α agents to interact with osteosarcoma cells, we examined the expression of interferon-α/β receptor in a series of osteosarcoma specimens.

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