Human Testing of Pesticides: Ethical and Scientific Considerations | Zendy

Alan H. Lockwood | Zendy

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Human Testing of Pesticides: Ethical and Scientific Considerations

Author(s) -

Alan H. Lockwood

Publication year - 2004

Publication title -

american journal of public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.284

H-Index - 264

eISSN - 1541-0048

pISSN - 0090-0036

DOI - 10.2105/ajph.94.11.1908

Subject(s) - agency (philosophy) , pesticide , process (computing) , business , informed consent , environmental health , actuarial science , risk analysis (engineering) , political science , medicine , computer science , alternative medicine , biology , sociology , social science , pathology , agronomy , operating system

I reviewed ethical and scientific aspects of 6 human pesticide-dosing studies submitted to the Environmental Protection Agency (EPA) for consideration during the pesticide reregistration process. All had serious ethical or scientific deficiencies-or both-including unacceptable informed consent procedures, unmanaged financial conflicts of interest, inadequate statistical power, inappropriate test methods and endpoints, and distorted results. Given today's knowledge of the effects of pesticides, there is no assurance that any such study can be completely free of short-term risks, long-term risks, or both. Therefore, there is no basis for allowing pesticide studies to continue or for using them during the pesticide reregistration process. An EPA committee that is free from political and financial conflicts of interest should review this practice.

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