Continuing female predominance in depressive illness. | Zendy

Andrew C. Leon | Zendy; Gerald L. Klerman | Zendy; Priya Wickramaratne | Zendy

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Continuing female predominance in depressive illness.

Author(s) -

Andrew C. Leon,

Gerald L. Klerman,

Priya Wickramaratne

Publication year - 1993

Publication title -

american journal of public health

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.284

H-Index - 264

eISSN - 1541-0048

pISSN - 0090-0036

DOI - 10.2105/ajph.83.5.754

Subject(s) - depression (economics) , major depressive disorder , demography , psychiatry , mental health , proband , medicine , psychology , young adult , cohort , incidence (geometry) , vulnerability (computing) , clinical psychology , gerontology , biochemistry , chemistry , physics , cognition , sociology , gene , optics , economics , mutation , macroeconomics , computer security , computer science

This paper examines gender differences in temporal trends for major depressive disorder in childhood, adolescence, and young adulthood. The study sample, a high-risk group from the National Institute of Mental Health Collaborative Study on the Psychobiology of Depression, includes 2000 first-degree relatives of probands with affective disorder. The age-specific incidence rates were analyzed to determine the effect of gender, age, period, and cohort on depression by age 35. Women had nearly a twofold increase in risk of major depressive disorder, with rates peaking between adolescence and early adulthood. Vulnerability to depression was highest in the 1960s and 1970s. The rate increase in recent decades has not corresponded to a reduction in the gender differences.

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