Neonatal tetanus in Peru: risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test. | Zendy

Louis Vernacchio | Zendy; Guillermo Madico | Zendy; Manuela Verástegui | Zendy; F Diaz | Zendy; Timothy S. Collins | Zendy; Robert H. Gilman | Zendy

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Neonatal tetanus in Peru: risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test.

Author(s) -

Louis Vernacchio,

Guillermo Madico,

Manuela Verástegui,

F Diaz,

Timothy S. Collins,

Robert H. Gilman

Publication year - 1993

Publication title -

american journal of public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.284

H-Index - 264

eISSN - 1541-0048

pISSN - 0090-0036

DOI - 10.2105/ajph.83.12.1754

Subject(s) - toxoid , tetanus , medicine , antitoxin , immunity , neonatal tetanus , pregnancy , immunology , titer , antibody , immune system , vaccination , biology , toxin , microbiology and biotechnology , genetics

We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2%) had protective antitoxin titers (> or = 0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during the current pregnancy. A majority of women reporting no toxoid doses during the current pregnancy had at least one prenatal health care visit. We evaluated a toxoid skin test in 44 of the subjects, but it correlated poorly with the ELISA. The modified ELISA is a useful in vitro method for studying tetanus immunity in the developing world.

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