Open AccessRabies Vaccine Adsorbed: neutralizing antibody titers after three-dose pre-exposure vaccination.
Author(s) -
Byron S. Berlin
Publication year - 1990
Publication title -
american journal of public health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.284
H-Index - 264
eISSN - 1541-0048
pISSN - 0090-0036
DOI - 10.2105/ajph.80.4.476
Subject(s) - vaccination , rabies , medicine , titer , immunization , rabies vaccine , neutralizing antibody , virology , post exposure prophylaxis , neutralization , antibody titer , antibody , immunology , rabies virus
Field trials at several schools of veterinary medicine showed that three-dose pre-exposure rabies vaccination with Rabies Vaccine Adsorbed developed by the Michigan Department of Health elicited neutralization antibody in practically all recipients two to three weeks after immunization. Titers declined during the first six months after vaccination. However, by 18 to 24 months, 98 percent of recipients still had titers equal or greater than a 1:5 dilution of serum.