Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure. | Zendy

M. J. Jarvis | Zendy; Michael A. Russell | Zendy; Neal L. Benowitz | Zendy; C Feyerabend | Zendy

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Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure.

Author(s) -

M. J. Jarvis,

Michael A. Russell,

Neal L. Benowitz,

C Feyerabend

Publication year - 1988

Publication title -

american journal of public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.284

H-Index - 264

eISSN - 1541-0048

pISSN - 0090-0036

DOI - 10.2105/ajph.78.6.696

Subject(s) - cotinine , urine , saliva , body fluid , nicotine , tobacco smoke , medicine , physiology , toxicology , environmental health , biology

Cotinine elimination from plasma, saliva, and urine was studied over 11 days in five subjects (three nonsmokers and two occasional smokers). Half-lives for cotinine averaged 16-19 hours in the different body fluids (range 10 to 27 hours between subjects). There was no tendency for the half-life in saliva to be longer than in plasma or urine. We conclude that choice of body fluid for cotinine assay in smoking studies should depend on practical rather than pharmacokinetic considerations.

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