Open AccessIntradermal immunization with human diploid cell rabies vaccine: serological and clinical responses of immunized persons to intradermal booster vaccination.
Author(s) -
M. J. Burridge,
John W. Sumner,
George M. Baer
Publication year - 1984
Publication title -
american journal of public health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.284
H-Index - 264
eISSN - 1541-0048
pISSN - 0090-0036
DOI - 10.2105/ajph.74.5.503
Subject(s) - rabies , rabies vaccine , medicine , vaccination , immunization , immunology , titer , serology , virology , duck embryo vaccine , volunteer , booster dose , booster (rocketry) , intradermal injection , antibody , rabies virus , biology , physics , astronomy , agronomy
Rabies antibody titers ranged from 0-9.3 IU/mL in 117 human volunteers one year after intradermal vaccination with one or two doses of human diploid cell rabies vaccine (HDCV). At that time, each volunteer received one 0.1-mL booster dose of HDCV intradermally. All 117 volunteers showed good anamnestic responses, with antibody titers rising to 0.5-54.3 IU/mL within seven days of booster injection. Vaccine safety was good; only minor reactions were experienced, all of which resolved spontaneously.