Late effects following isoniazid therapy. | Zendy

John D. Boice | Zendy; J F Fraumeni | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Late effects following isoniazid therapy.

Author(s) -

John D. Boice,

J F Fraumeni

Publication year - 1980

Publication title -

american journal of public health

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.284

H-Index - 264

eISSN - 1541-0048

pISSN - 0090-0036

DOI - 10.2105/ajph.70.9.987

Subject(s) - isoniazid , medicine , cirrhosis , tuberculosis , pneumothorax , legionnaires' disease , isonicotinic acid , cancer , liver cancer , breast cancer , disease , gastroenterology , surgery , hydrazide , pathology , chemistry , legionella pneumophila , organic chemistry , biology , bacteria , genetics

Amont 338 women treated in Massachusetts with isoniazid (isonicotinic acid hydrazide = INH) for pulmonary tuberculosis, no excess cancer deaths occurred (8 observed vs 8.3 expected) after 23 years (12.9 mean) of follow-up. There was an excess of cancer deaths (54 vs 35.7) among 1,090 patients who did not receive INH, partly due to radiogenic breast cancer resulting from multiple chest fluoroscopies to monitor pneumothorax. Increased deaths from liver cirrhosis (5 vs 0.8) were observed following INH use, suggesting that chronic as well as acute liver disease complicate this treatment.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research