Early Hits and Long-Term Consequences: Tracking the Lasting Impact of Prenatal Smoke Exposure on Telomere Length in Children | Zendy

Katherine P. Theall | Zendy; Sarah McKasson | Zendy; Emily Mabile | Zendy; Lauren Futrell Dunaway | Zendy; Stacy S. Drury | Zendy

Open Access

Early Hits and Long-Term Consequences: Tracking the Lasting Impact of Prenatal Smoke Exposure on Telomere Length in Children

Author(s) -

Katherine P. Theall,

Sarah McKasson,

Emily Mabile,

Lauren Futrell Dunaway,

Stacy S. Drury

Publication year - 2013

Publication title -

american journal of public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.284

H-Index - 264

eISSN - 1541-0048

pISSN - 0090-0036

DOI - 10.2105/ajph.2012.301208

Subject(s) - telomere , term (time) , prenatal exposure , medicine , environmental health , smoke , tracking (education) , pediatrics , demography , genetics , psychology , pregnancy , biology , offspring , geography , dna , pedagogy , physics , quantum mechanics , sociology , meteorology

We examined the association between telomere length and prenatal tobacco exposure (PTE) in 104 children aged 4 to 14 years. Salivary telomere length (STL) was determined from salivary DNA using quantitative polymerase chain reaction. Of the children, 18% had maternal reported PTE. Mean STL was significantly lower among children with PTE (6.4 vs 7.5, P < .05). Findings extend the literature demonstrating the negative long-term effects of PTE to include a cellular marker of aging linked to multiple negative health outcomes.

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