Radiotherapy for Krukenberg tumor: a case report

Krukenberg tumor (KT) is a rare metastatic ovarian tumor originating from other malignancy. Although there is neither randomized trial nor standard treatment guidelines, review studies show that cytoreductive surgery, chemotherapy and radiotherapy improve survival for patients with KT. Here, we report a case of a 76-year-old Taiwanese woman initially diagnosed with unresectable KT originating from colon origin (16 cm × 14 cm × 13 cm). She had progressive disease after second line of systemic treatment. Then, she received volumetric arc therapy of 46 Gy with 2.3 Gy per fraction to gross tumor volume and additional boost dose of 25 Gy with 2.5 Gy per fraction. Eventually, she had survived for 4 years since diagnosed with KT, and had locally controlled disease for 2 years. From our experience, dose escalation and higher fraction dose radiotherapy may provide better local control for KT.