Ras pathway mutation feature in the same individuals at diagnosis and relapse of childhood acute lymphoblastic leukemia | Zendy

Honghong Zhang | Zendy; Hongsheng Wang | Zendy; Xiaowen Qian | Zendy; Xiaohua Zhu | Zendy; Hui Miao | Zendy; Yi Yu | Zendy; Jianhua Meng | Zendy; Jun Le | Zendy; Junye Jiang | Zendy; Ping Cao | Zendy; Wen-Jing Jiang | Zendy; Ping Wang | Zendy; Yang Fu | Zendy; Jun Li | Zendy; Maoxiang Qian | Zendy; Xiaowen Zhai | Zendy

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Ras pathway mutation feature in the same individuals at diagnosis and relapse of childhood acute lymphoblastic leukemia

Author(s) -

Honghong Zhang,

Hongsheng Wang,

Xiaowen Qian,

Xiaohua Zhu,

Hui Miao,

Yi Yu,

Jianhua Meng,

Jun Le,

Junye Jiang,

Ping Cao,

Wen-Jing Jiang,

Ping Wang,

Yang Fu,

Jun Li,

Maoxiang Qian,

Xiaowen Zhai

Publication year - 2020

Publication title -

translational pediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.702

H-Index - 13

eISSN - 2224-4344

pISSN - 2224-4336

DOI - 10.21037/tp.2020.01.07

Subject(s) - medicine , neuroblastoma ras viral oncogene homolog , kras , oncology , somatic evolution in cancer , cancer , colorectal cancer

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, while relapse and refractory ALL remains a leading cause of death in children. However, paired ALL samples of initial diagnosis and relapse subjected to next-generation sequencing (NGS) could construct clonal lineage changes, and help to explore the key issues in the evolutionary process of tumor clones. Therefore, we aim to analyze gene alterations during the initial diagnosis and relapse of ALL patients and to explore the underlying mechanism.

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