English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Immune checkpoint inhibitors (ICIs), including pembrolizumab and nivolumab, both monoclonal antibodies against programmed cell death-1 (PD-1), and antibodies targeting the programmed cell death receptor ligand-1 (PD-L1) such as atezolizumab or durvalumab, have heralded impressive therapeutic advances in previously treated advanced non-small cell lung cancer (NSCLC). Several studies have compared ICI with standard chemotherapy, and reported an unprecedented 5-year overall survival (OS) of 15% with ICIs (1). This breakthrough was followed by a further report of a survival benefit when ICIs were administered in the first-line setting in an unselected population, both as single agents and in combination with chemotherapy or ipilimumab, compared with platinum-based chemotherapy (2).

CheckMate 153 study: are age and performance status relevant for immune checkpoint inhibitor efficacy?