Pathophysiology of gastroesophageal reflux disease—which factors are important? | Zendy

KarlHermann Fuchs | Zendy; Arielle M. Lee | Zendy; Wolfram Breithaupt | Zendy; Gábor Varga | Zendy; Benjamin Babic | Zendy; Santiago Horgan | Zendy

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Pathophysiology of gastroesophageal reflux disease—which factors are important?

Author(s) -

KarlHermann Fuchs,

Arielle M. Lee,

Wolfram Breithaupt,

Gábor Varga,

Benjamin Babic,

Santiago Horgan

Publication year - 2021

Publication title -

translational gastroenterology and hepatology

Language(s) - English

Resource type - Journals

ISSN - 2415-1289

DOI - 10.21037/tgh.2020.02.12

Subject(s) - medicine , gerd , hiatal hernia , gastroenterology , esophagitis , reflux , pathophysiology , esophageal motility disorder , gastric emptying , esophagus , body mass index , high resolution manometry , nerd , population , stomach , disease , environmental health

Numerous publications on the pathophysiology of gastroesophageal reflux disease (GERD) demonstrate the multifactorial background of this benign disorder, highly prevalent in the western industrialized countries of North America and Europe (1-7). Understanding of the pathophysiology of reflux has expanded in recent decades with the advent of new diagnostic technology (8-15). The disease is associated with reflux of gastric contents into the esophagus causing mainly increased acid exposure in the esophageal lumen and/or esophagitis (5,14). GERD often Original Article

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