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Numerous publications on the pathophysiology of gastroesophageal reflux disease (GERD) demonstrate the multifactorial background of this benign disorder, highly prevalent in the western industrialized countries of North America and Europe (1-7). Understanding of the pathophysiology of reflux has expanded in recent decades with the advent of new diagnostic technology (8-15). The disease is associated with reflux of gastric contents into the esophagus causing mainly increased acid exposure in the esophageal lumen and/or esophagitis (5,14). GERD often Original Article

Pathophysiology of gastroesophageal reflux disease—which factors are important?