The significance of plasma D-dimer level in predicting high risk factors of endometrial cancer | Zendy

Yujia Huang | Zendy; Bilan Li | Zendy

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The significance of plasma D-dimer level in predicting high risk factors of endometrial cancer

Author(s) -

Yujia Huang,

Bilan Li

Publication year - 2020

Publication title -

translational cancer research

Language(s) - English

Resource type - Journals

eISSN - 2219-6803

pISSN - 2218-676X

DOI - 10.21037/tcr.2020.04.22

Subject(s) - medicine , endometrial cancer , d dimer , gastroenterology , cancer , lymphovascular invasion , stage (stratigraphy) , retrospective cohort study , clinical significance , lymph node , oncology , metastasis , paleontology , biology

The cases of endometrial cancer (EC) diagnosed are increasing (1,2). Surgery is still the standard treatment for early-stage EC (3). However, treatment strategies would be different for EC patients with different incidence of recurrence after surgery. Based on FIGO stage, grade and histotype, EC patients are divided into low risk and high risk groups for the risk of tumor recurrence (4). Biomarkers could help identify people with high risk of cancer (5). Therefore, it is urgent to develop new reliable biomarkers to stratify EC patients into risk categories for individualized therapy (6). D-dimer is involved in coagulation activation and has been applied for the diagnosis of venous thromboembolism (VTE) (7). In addition, D-dimer levels increase in several kinds of cancer, and correlate with poor prognosis and resistance to treatment (8). However, a recent study suggested that D-dimer levels may not be a promising independent prognostic factor for EC (9). To further investigate the significance of plasma D-dimer in the prediction of high risk group of EC patients, in this Original Article

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