B4GALNT1 enhances cell proliferation and growth in oral squamous cell carcinoma via p38 and JNK MAPK pathway | Zendy

Shaohong Jing | Zendy; Zhaoming Deng | Zendy; Lizhong Liang | Zendy; Jun Liang | Zendy

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B4GALNT1 enhances cell proliferation and growth in oral squamous cell carcinoma via p38 and JNK MAPK pathway

Author(s) -

Shaohong Jing,

Zhaoming Deng,

Lizhong Liang,

Jun Liang

Publication year - 2020

Publication title -

translational cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.254

H-Index - 30

eISSN - 2219-6803

pISSN - 2218-676X

DOI - 10.21037/tcr.2020.03.73

Subject(s) - cell growth , apoptosis , gene knockdown , gene silencing , cell cycle , small hairpin rna , carcinogenesis , cell , cancer research , transfection , biology , mapk/erk pathway , cell cycle checkpoint , microbiology and biotechnology , signal transduction , cell culture , cancer , gene , genetics

Head and neck cancer ranks the sixth among the most common malignant tumor around the world (1). It is also reported that oral squamous cell carcinoma (OSCC) occupies almost 90% of the cancer found in head and neck region (2). The prognosis of the cancer is highly associated with the stages, differentiation as well as the lymph node metastasis of the tumor (3-5). Although the diagnostic and therapeutic measures including surgical resection, radiotherapy, chemotherapy and comprehensive sequence therapy have been proven remarkable measures to achieve better life quality recently, the morbidity and mortality of OSCC remain high and the overall 5-year survival rate for OSCC patients is reported to be relatively low, which rendering OSCC still a global concern of cancer-related death (3,6). Beta-1,4-N-Acetyl-Galactosaminyltransferase 1 Original Article

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