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Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China; Department of Orthopedic Oncology, Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China Contributions: (I) Conception and design: W Yan, J Xiao; (II) Administrative support: W Yan, J Xiao; (III) Provision of study materials or patients: W Yan, J Xiao; (IV) Collection and assembly of data: S Chen, Z Zhou; (V) Data analysis and interpretation: X Ku, Y Xu; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Dr. Xin Ku. Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China. Email: xinku@sjtu.edu.cn; Prof. Wei Yan. Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China. Email: weiyan_99@uwalumni.com, weiyan@sjtu.edu.cn; Prof. Jianru Xiao. Department of Orthopedic Oncology, Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China. Email: jianruxiao83@163.com.

translational cancer research

Data independent acquisition-mass spectrometry (DIA-MS)-based comprehensive profiling of bone metastatic cancers revealed molecular fingerprints to assist clinical classifications for bone metastasis of unknown primary (BMUP)