Circulating guanylyl cyclase C (GCC) mRNA is a reliable metastatic predictor and prognostic index of colorectal cancer | Zendy

Lai Jiang | Zendy; Jianguo Feng | Zendy; Gang Wang | Zendy; Yuping Zhu | Zendy; Haixing Ju | Zendy; Dechuan Li | Zendy; Yong Liu | Zendy

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Circulating guanylyl cyclase C (GCC) mRNA is a reliable metastatic predictor and prognostic index of colorectal cancer

Author(s) -

Lai Jiang,

Jianguo Feng,

Gang Wang,

Yuping Zhu,

Haixing Ju,

Dechuan Li,

Yong Liu

Publication year - 2020

Publication title -

translational cancer research

Language(s) - English

Resource type - Journals

eISSN - 2219-6803

pISSN - 2218-676X

DOI - 10.21037/tcr.2020.02.34

Subject(s) - colorectal cancer , medicine , nomogram , metastasis , oncology , stage (stratigraphy) , cancer , messenger rna , guanylate cyclase 2c , real time polymerase chain reaction , cancer research , biology , receptor , cyclase , gene , paleontology , biochemistry

Colorectal cancer (CRC) is the third-leading cause of cancer-related death worldwide due to its tendency to metastasize to distant organs (1). In spite of effective treatments like standard radical surgery and adjuvant therapies, circulating tumor cells (CTCs) still lead to unexpected clinical metastases during the follow-up process, and do so partially in early-stage CRC patients (2,3). CTC has been shown to play a crucial role in tumor metastasis from the local primary site to distant target organs (4,5). It is also a valuable carrier for both diagnosing micrometastasis and predicting the patients’ prognosis in the advanced stage of the tumor (6,7). CTCs are currently considered to be reliable predictors of the overall survival (OS) and progression-free survival (PFS) in local advanced Original Article

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