English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Among the most prevalent forms of malignant tumors seen in children and teenagers, osteosarcoma (OS) is a bone disease originating from mesenchymal stem cells (1,2). OS is characterized by early metastasis, and approximately 15–25% of patients have detectable lung metastases at the time of their diagnosis (3). Tumor resection and nonspecific combination chemotherapy are the preferred modes of treatment for OS patients (4,5). With the advances made in relation to primary tumor treatment, patients with the disease have seen a rise in their long-term survival rate (6); however, for patients with distant metastasis, the survival rate remains very low (7-9). It is essential to find new and more effective treatment targets for OS to improve the survival time of patients. Abnormal expression of high mobility group nucleosome binding domain 2 (HMGN2) is associated with multiple tumors (10,11). HMGN2 takes on a key role in breast cancer progression (12-14) and inhibits the growth and Original Article

Exogenous HMGN2 inhibits the migration and invasion of osteosarcoma cell lines