Long non-coding RNA MEG3 functions as a competing endogenous RNA of miR-93 to regulate bladder cancer progression via PI3K/AKT/mTOR pathway
Author(s) -
Xinrong Fan,
Houfeng Huang,
Zhigang Ji,
Quanzong Mao
Publication year - 2020
Publication title -
translational cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.254
H-Index - 30
eISSN - 2219-6803
pISSN - 2218-676X
DOI - 10.21037/tcr.2020.01.70
Subject(s) - meg3 , pi3k/akt/mtor pathway , carcinogenesis , competing endogenous rna , protein kinase b , cell growth , long non coding rna , cancer research , reporter gene , biology , microbiology and biotechnology , rna , chemistry , signal transduction , gene expression , gene , biochemistry
Bladder cancer (BC) is emerged as a highly prevalent malignancy associated with high morbidity and mortality and its incidence has increased over the last decades (1,2). At present, various therapies including surgery, chemotherapy and radiation treatment have been widely applied in the therapy of BC (1). However, the advances in BC treatment have been greatly restricted in the past decades due to the lack of understanding of its pathogenic mechanism. Thus, it is urgent to elaborate the pathogenic mechanism of BC. Recently, long noncoding RNAs (lncRNAs) have emerged as the Original Article
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